The p75 neurotrophin receptor interacts with multiple MAGE proteins

Marianna Tcherpakov, Francisca C. Bronfman, Silvestro G. Conticello, Anna Vaskovsky, Zehava Levy, Michio Niinobe, Kazuaki Yoshikawa, Ernest Arenas, Mike Fainzilber

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


The p75 neurotrophin receptor has been implicated in diverse aspects of neurotrophin signaling, but the mechanisms by which its effects are mediated are not well understood. Here we identify two MAGE proteins, necdin and MAGE-H1, as interactors for the intracellular domain of p75 and show that the interaction is enhanced by ligand stimulation. PC12 cells transfected with necdin or MAGE-H1 exhibit accelerated differentiation in response to nerve growth factor. Expression of these two MAGE proteins is predominantly cytoplasmic in PC12 cells, and needin was found to be capable of homodimerization, suggesting that it may act as a cytoplasmic adaptor to recruit a signaling complex to p75. These findings indicate that diverse MAGE family members can interact with the p75 receptor and highlight type II MAGE proteins as a potential family of interactors for signaling proteins containing type II death domains.

Original languageEnglish
Pages (from-to)49101-49104
Number of pages4
JournalJournal of Biological Chemistry
Issue number51
Publication statusPublished - 20 Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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