The InterSePT scale for suicidal thinking reliability and validity

J. P. Lindenmayer; Pal Czobor; Larry Alphs; Ann Marie Nathan; Ravi Anand; Zahur Islam; James C.Y. Chou; Saide Altinsan; Siemion Altman; Likiana Avigo; Richard Balon; Vanda Beněsová; Luis Bengochea; Alberto Bertoldi; Elisabeth Bokowska; Marc Bourgeois; Bernardo Carpiniello; James Chou; Guy Chouinard; Libor Chvila; Jean Dalery; Liliana Dell'Osso; Carl Eisdorfer; Robin A. Emsley; T. A. Fahy; Vera Folnegovic; Sophie Frangou; Pedro Gargoloff; Alberto Giannelli; Alan I. Green; Richard Greenberg; George T. Grossberg; George Hsu; Naveed Iqbal; Miro Jakovljevic; Richard C. Josiassen; Akos Kassaifarkas; Frederic Khidichian; Mary Ann Knesevich; Jack Krasuski; Veronica Larach; Michael Lesem; Pierre Michel Llorca; Jean Pierre Lindenmayer; Stephen Martin; Muriel Maurel-Raymondet; Herbert Meltzer; Laszlo Mod; Eva Morik; Carlos Morra; Ann Mortimer; Gyorgy Ostorharics-Horvath; Ivo Paclt; Jorg J. Pahl; Jeffrey Lee Peters; Rosario Piolo; Michael G. Plopper; Thomas Posever; Delbert Robinson; Carlo Andrea Robotti; Oladapo Tomori; Santha Vaidain; Zdèoka Vyhnándová; Marie Agathe Zimmerman

doi:10.1016/S0920-9964(02)00335-3

The InterSePT scale for suicidal thinking reliability and validity

J. P. Lindenmayer, Pal Czobor, Larry Alphs, Ann Marie Nathan, Ravi Anand, Zahur Islam, James C.Y. Chou, Saide Altinsan, Siemion Altman, Likiana Avigo, Richard Balon, Vanda Beněsová, Luis Bengochea, Alberto Bertoldi, Elisabeth Bokowska, Marc Bourgeois, Bernardo Carpiniello, James Chou, Guy Chouinard, Libor ChvilaJean Dalery, Liliana Dell'Osso, Carl Eisdorfer, Robin A. Emsley, T. A. Fahy, Vera Folnegovic, Sophie Frangou, Pedro Gargoloff, Alberto Giannelli, Alan I. Green, Richard Greenberg, George T. Grossberg, George Hsu, Naveed Iqbal, Miro Jakovljevic, Richard C. Josiassen, Akos Kassaifarkas, Frederic Khidichian, Mary Ann Knesevich, Jack Krasuski, Veronica Larach, Michael Lesem, Pierre Michel Llorca, Jean Pierre Lindenmayer, Stephen Martin, Muriel Maurel-Raymondet, Herbert Meltzer, Laszlo Mod, Eva Morik, Carlos Morra, Ann Mortimer, Gyorgy Ostorharics-Horvath, Ivo Paclt, Jorg J. Pahl, Jeffrey Lee Peters, Rosario Piolo, Michael G. Plopper, Thomas Posever, Delbert Robinson, Carlo Andrea Robotti, Oladapo Tomori, Santha Vaidain, Zdèoka Vyhnándová, Marie Agathe Zimmerman

Medicine School

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

Background: The InterSePT Scale for Suicidal Thinking (ISST) is a 12-item instrument for the assessment of current suicidal ideation in patients with schizophrenia and schizoaffective disorders. We report the psychometric characteristics of this new scale based on two studies. Method: In Study 1, 22 inpatients with schizophrenia and schizoaffective disorders, who had recently attempted suicide or engaged in suicidal ideation, were rated by three trained independent raters to examine interrater reliability. In Study 2, a total of 980 patients with schizophrenia or schizoaffective disorder with a history of suicidal ideation in the past 36 months were enrolled in a 2-year industry-sponsored suicide prevention study. At baseline, these patients were administered the ISST and the Clinical Global Impression Scale for Severity of Suicidality (CGI-SS) by the Principal Investigator (PI) and by a blinded rater (BR), who also administered the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale (CDS), and the Scale of Functioning (SOF). Indices of internal reliability, construct and discriminant validity were examined. Results: The intraclass correlation coefficient (ICC) for the total ISST score for the 22 subjects in Study 1 was 0.90 and mean weighted item kappa coefficients ranged from 0.66 to 0.92. In Study 2, internal reliability (Cronbach alpha) was high, ranging from 0.86 to 0.89 for the individual items, and the overall Cronbach alpha coefficient for all items was 0.88. The ISST (PI) total score was highly correlated with the CGI-SS by the blind rater (r=0.61, p<0.0001). ISST total scores significantly differentiated the different levels of CGI-SS (F=519.2; p<0.0001). Results of construct and discriminant validity analyses are also presented. Conclusion: The ISST is a reliable and valid instrument for the assessment of current suicidal thinking in patients with schizophrenia and schizoaffective disorder by both clinicians and researchers.

Original language	English
Pages (from-to)	161-170
Number of pages	10
Journal	Schizophrenia Research
Volume	63
Issue number	1-2
DOIs	https://doi.org/10.1016/S0920-9964(02)00335-3
Publication status	Published - 1 Sept 2003

Keywords

ISST
Schizoaffective disorder
Schizophrenia
Suicidal ideation

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/S0920-9964(02)00335-3

Cite this

Lindenmayer, J. P., Czobor, P., Alphs, L., Nathan, A. M., Anand, R., Islam, Z., Chou, J. C. Y., Altinsan, S., Altman, S., Avigo, L., Balon, R., Beněsová, V., Bengochea, L., Bertoldi, A., Bokowska, E., Bourgeois, M., Carpiniello, B., Chou, J., Chouinard, G., ... Zimmerman, M. A. (2003). The InterSePT scale for suicidal thinking reliability and validity. Schizophrenia Research, 63(1-2), 161-170. https://doi.org/10.1016/S0920-9964(02)00335-3

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title = "The InterSePT scale for suicidal thinking reliability and validity",

abstract = "Background: The InterSePT Scale for Suicidal Thinking (ISST) is a 12-item instrument for the assessment of current suicidal ideation in patients with schizophrenia and schizoaffective disorders. We report the psychometric characteristics of this new scale based on two studies. Method: In Study 1, 22 inpatients with schizophrenia and schizoaffective disorders, who had recently attempted suicide or engaged in suicidal ideation, were rated by three trained independent raters to examine interrater reliability. In Study 2, a total of 980 patients with schizophrenia or schizoaffective disorder with a history of suicidal ideation in the past 36 months were enrolled in a 2-year industry-sponsored suicide prevention study. At baseline, these patients were administered the ISST and the Clinical Global Impression Scale for Severity of Suicidality (CGI-SS) by the Principal Investigator (PI) and by a blinded rater (BR), who also administered the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale (CDS), and the Scale of Functioning (SOF). Indices of internal reliability, construct and discriminant validity were examined. Results: The intraclass correlation coefficient (ICC) for the total ISST score for the 22 subjects in Study 1 was 0.90 and mean weighted item kappa coefficients ranged from 0.66 to 0.92. In Study 2, internal reliability (Cronbach alpha) was high, ranging from 0.86 to 0.89 for the individual items, and the overall Cronbach alpha coefficient for all items was 0.88. The ISST (PI) total score was highly correlated with the CGI-SS by the blind rater (r=0.61, p<0.0001). ISST total scores significantly differentiated the different levels of CGI-SS (F=519.2; p<0.0001). Results of construct and discriminant validity analyses are also presented. Conclusion: The ISST is a reliable and valid instrument for the assessment of current suicidal thinking in patients with schizophrenia and schizoaffective disorder by both clinicians and researchers.",

keywords = "ISST, Schizoaffective disorder, Schizophrenia, Suicidal ideation",

author = "Lindenmayer, {J. P.} and Pal Czobor and Larry Alphs and Nathan, {Ann Marie} and Ravi Anand and Zahur Islam and Chou, {James C.Y.} and Saide Altinsan and Siemion Altman and Likiana Avigo and Richard Balon and Vanda Ben{\v e}sov{\'a} and Luis Bengochea and Alberto Bertoldi and Elisabeth Bokowska and Marc Bourgeois and Bernardo Carpiniello and James Chou and Guy Chouinard and Libor Chvila and Jean Dalery and Liliana Dell'Osso and Carl Eisdorfer and Emsley, {Robin A.} and Fahy, {T. A.} and Vera Folnegovic and Sophie Frangou and Pedro Gargoloff and Alberto Giannelli and Green, {Alan I.} and Richard Greenberg and Grossberg, {George T.} and George Hsu and Naveed Iqbal and Miro Jakovljevic and Josiassen, {Richard C.} and Akos Kassaifarkas and Frederic Khidichian and Knesevich, {Mary Ann} and Jack Krasuski and Veronica Larach and Michael Lesem and Llorca, {Pierre Michel} and Lindenmayer, {Jean Pierre} and Stephen Martin and Muriel Maurel-Raymondet and Herbert Meltzer and Laszlo Mod and Eva Morik and Carlos Morra and Ann Mortimer and Gyorgy Ostorharics-Horvath and Ivo Paclt and Pahl, {Jorg J.} and Peters, {Jeffrey Lee} and Rosario Piolo and Plopper, {Michael G.} and Thomas Posever and Delbert Robinson and Robotti, {Carlo Andrea} and Oladapo Tomori and Santha Vaidain and Zd{\`e}oka Vyhn{\'a}ndov{\'a} and Zimmerman, {Marie Agathe}",

year = "2003",

month = sep,

day = "1",

doi = "10.1016/S0920-9964(02)00335-3",

language = "English",

volume = "63",

pages = "161--170",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "1-2",

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Lindenmayer, JP, Czobor, P, Alphs, L, Nathan, AM, Anand, R, Islam, Z, Chou, JCY, Altinsan, S, Altman, S, Avigo, L, Balon, R, Beněsová, V, Bengochea, L, Bertoldi, A, Bokowska, E, Bourgeois, M, Carpiniello, B, Chou, J, Chouinard, G, Chvila, L, Dalery, J, Dell'Osso, L, Eisdorfer, C, Emsley, RA, Fahy, TA, Folnegovic, V, Frangou, S, Gargoloff, P, Giannelli, A, Green, AI, Greenberg, R, Grossberg, GT, Hsu, G, Iqbal, N, Jakovljevic, M, Josiassen, RC, Kassaifarkas, A, Khidichian, F, Knesevich, MA, Krasuski, J, Larach, V, Lesem, M, Llorca, PM, Lindenmayer, JP, Martin, S, Maurel-Raymondet, M, Meltzer, H, Mod, L, Morik, E, Morra, C, Mortimer, A, Ostorharics-Horvath, G, Paclt, I, Pahl, JJ, Peters, JL, Piolo, R, Plopper, MG, Posever, T, Robinson, D, Robotti, CA, Tomori, O, Vaidain, S, Vyhnándová, Z & Zimmerman, MA 2003, 'The InterSePT scale for suicidal thinking reliability and validity', Schizophrenia Research, vol. 63, no. 1-2, pp. 161-170. https://doi.org/10.1016/S0920-9964(02)00335-3

TY - JOUR

T1 - The InterSePT scale for suicidal thinking reliability and validity

AU - Lindenmayer, J. P.

AU - Czobor, Pal

AU - Alphs, Larry

AU - Nathan, Ann Marie

AU - Anand, Ravi

AU - Islam, Zahur

AU - Chou, James C.Y.

AU - Altinsan, Saide

AU - Altman, Siemion

AU - Avigo, Likiana

AU - Balon, Richard

AU - Beněsová, Vanda

AU - Bengochea, Luis

AU - Bertoldi, Alberto

AU - Bokowska, Elisabeth

AU - Bourgeois, Marc

AU - Carpiniello, Bernardo

AU - Chou, James

AU - Chouinard, Guy

AU - Chvila, Libor

AU - Dalery, Jean

AU - Dell'Osso, Liliana

AU - Eisdorfer, Carl

AU - Emsley, Robin A.

AU - Fahy, T. A.

AU - Folnegovic, Vera

AU - Frangou, Sophie

AU - Gargoloff, Pedro

AU - Giannelli, Alberto

AU - Green, Alan I.

AU - Greenberg, Richard

AU - Grossberg, George T.

AU - Hsu, George

AU - Iqbal, Naveed

AU - Jakovljevic, Miro

AU - Josiassen, Richard C.

AU - Kassaifarkas, Akos

AU - Khidichian, Frederic

AU - Knesevich, Mary Ann

AU - Krasuski, Jack

AU - Larach, Veronica

AU - Lesem, Michael

AU - Llorca, Pierre Michel

AU - Lindenmayer, Jean Pierre

AU - Martin, Stephen

AU - Maurel-Raymondet, Muriel

AU - Meltzer, Herbert

AU - Mod, Laszlo

AU - Morik, Eva

AU - Morra, Carlos

AU - Mortimer, Ann

AU - Ostorharics-Horvath, Gyorgy

AU - Paclt, Ivo

AU - Pahl, Jorg J.

AU - Peters, Jeffrey Lee

AU - Piolo, Rosario

AU - Plopper, Michael G.

AU - Posever, Thomas

AU - Robinson, Delbert

AU - Robotti, Carlo Andrea

AU - Tomori, Oladapo

AU - Vaidain, Santha

AU - Vyhnándová, Zdèoka

AU - Zimmerman, Marie Agathe

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background: The InterSePT Scale for Suicidal Thinking (ISST) is a 12-item instrument for the assessment of current suicidal ideation in patients with schizophrenia and schizoaffective disorders. We report the psychometric characteristics of this new scale based on two studies. Method: In Study 1, 22 inpatients with schizophrenia and schizoaffective disorders, who had recently attempted suicide or engaged in suicidal ideation, were rated by three trained independent raters to examine interrater reliability. In Study 2, a total of 980 patients with schizophrenia or schizoaffective disorder with a history of suicidal ideation in the past 36 months were enrolled in a 2-year industry-sponsored suicide prevention study. At baseline, these patients were administered the ISST and the Clinical Global Impression Scale for Severity of Suicidality (CGI-SS) by the Principal Investigator (PI) and by a blinded rater (BR), who also administered the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale (CDS), and the Scale of Functioning (SOF). Indices of internal reliability, construct and discriminant validity were examined. Results: The intraclass correlation coefficient (ICC) for the total ISST score for the 22 subjects in Study 1 was 0.90 and mean weighted item kappa coefficients ranged from 0.66 to 0.92. In Study 2, internal reliability (Cronbach alpha) was high, ranging from 0.86 to 0.89 for the individual items, and the overall Cronbach alpha coefficient for all items was 0.88. The ISST (PI) total score was highly correlated with the CGI-SS by the blind rater (r=0.61, p<0.0001). ISST total scores significantly differentiated the different levels of CGI-SS (F=519.2; p<0.0001). Results of construct and discriminant validity analyses are also presented. Conclusion: The ISST is a reliable and valid instrument for the assessment of current suicidal thinking in patients with schizophrenia and schizoaffective disorder by both clinicians and researchers.

AB - Background: The InterSePT Scale for Suicidal Thinking (ISST) is a 12-item instrument for the assessment of current suicidal ideation in patients with schizophrenia and schizoaffective disorders. We report the psychometric characteristics of this new scale based on two studies. Method: In Study 1, 22 inpatients with schizophrenia and schizoaffective disorders, who had recently attempted suicide or engaged in suicidal ideation, were rated by three trained independent raters to examine interrater reliability. In Study 2, a total of 980 patients with schizophrenia or schizoaffective disorder with a history of suicidal ideation in the past 36 months were enrolled in a 2-year industry-sponsored suicide prevention study. At baseline, these patients were administered the ISST and the Clinical Global Impression Scale for Severity of Suicidality (CGI-SS) by the Principal Investigator (PI) and by a blinded rater (BR), who also administered the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale (CDS), and the Scale of Functioning (SOF). Indices of internal reliability, construct and discriminant validity were examined. Results: The intraclass correlation coefficient (ICC) for the total ISST score for the 22 subjects in Study 1 was 0.90 and mean weighted item kappa coefficients ranged from 0.66 to 0.92. In Study 2, internal reliability (Cronbach alpha) was high, ranging from 0.86 to 0.89 for the individual items, and the overall Cronbach alpha coefficient for all items was 0.88. The ISST (PI) total score was highly correlated with the CGI-SS by the blind rater (r=0.61, p<0.0001). ISST total scores significantly differentiated the different levels of CGI-SS (F=519.2; p<0.0001). Results of construct and discriminant validity analyses are also presented. Conclusion: The ISST is a reliable and valid instrument for the assessment of current suicidal thinking in patients with schizophrenia and schizoaffective disorder by both clinicians and researchers.

KW - ISST

KW - Schizoaffective disorder

KW - Schizophrenia

KW - Suicidal ideation

UR - http://www.scopus.com/inward/record.url?scp=10744221706&partnerID=8YFLogxK

U2 - 10.1016/S0920-9964(02)00335-3

DO - 10.1016/S0920-9964(02)00335-3

M3 - Article

C2 - 12892870

AN - SCOPUS:10744221706

SN - 0920-9964

VL - 63

SP - 161

EP - 170

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-2

ER -

The InterSePT scale for suicidal thinking reliability and validity

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