The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression

Daniela Siel; Alexandra Loaiza; Sonia Vidal; Mario Caruffo; Rodolfo Paredes; Galia Ramirez; Lisette Lapierre; Cristóbal Briceño; Oliver Pérez; Leonardo Sáenz

doi:10.1111/aji.12772

The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression

Daniela Siel, Alexandra Loaiza, Sonia Vidal, Mario Caruffo, Rodolfo Paredes, Galia Ramirez, Lisette Lapierre, Cristóbal Briceño, Oliver Pérez, Leonardo Sáenz

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

Original language	English
Article number	e12772
Journal	American Journal of Reproductive Immunology
Volume	79
Issue number	1
DOIs	https://doi.org/10.1111/aji.12772
Publication status	Published - 1 Jan 2018

Keywords

adjuvants
GnRH-I
immunocastration
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/aji.12772

Cite this

Siel, D., Loaiza, A., Vidal, S., Caruffo, M., Paredes, R., Ramirez, G., Lapierre, L., Briceño, C., Pérez, O., & Sáenz, L. (2018). The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression. American Journal of Reproductive Immunology, 79(1), Article e12772. https://doi.org/10.1111/aji.12772

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title = "The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression",

abstract = "Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.",

keywords = "adjuvants, GnRH-I, immunocastration, vaccine",

author = "Daniela Siel and Alexandra Loaiza and Sonia Vidal and Mario Caruffo and Rodolfo Paredes and Galia Ramirez and Lisette Lapierre and Crist{\'o}bal Brice{\~n}o and Oliver P{\'e}rez and Leonardo S{\'a}enz",

note = "Funding Information: This study was supported by Grant FONDEF D08I1085, FONDECYT 11080015 and the scholarship Conicyt 21100217. The authors declare no financial conflicts of interest except as noted by author institutional affiliations.",

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doi = "10.1111/aji.12772",

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AU - Siel, Daniela

AU - Loaiza, Alexandra

AU - Vidal, Sonia

AU - Caruffo, Mario

AU - Paredes, Rodolfo

AU - Ramirez, Galia

AU - Lapierre, Lisette

AU - Briceño, Cristóbal

AU - Pérez, Oliver

AU - Sáenz, Leonardo

N1 - Funding Information: This study was supported by Grant FONDEF D08I1085, FONDECYT 11080015 and the scholarship Conicyt 21100217. The authors declare no financial conflicts of interest except as noted by author institutional affiliations.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

AB - Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

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The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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