The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression

Daniela Siel, Alexandra Loaiza, Sonia Vidal, Mario Caruffo, Rodolfo Paredes, Galia Ramirez, Lisette Lapierre, Cristóbal Briceño, Oliver Pérez, Leonardo Sáenz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

Original languageEnglish
Article numbere12772
JournalAmerican Journal of Reproductive Immunology
Volume79
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • adjuvants
  • GnRH-I
  • immunocastration
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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