The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression

Daniela Siel, Alexandra Loaiza, Sonia Vidal, Mario Caruffo, Rodolfo Paredes, Galia Ramirez, Lisette Lapierre, Cristóbal Briceño, Oliver Pérez, Leonardo Sáenz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

Original languageEnglish
Article numbere12772
JournalAmerican Journal of Reproductive Immunology
Volume79
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Gonadotropin-Releasing Hormone
Fertility
Hormones
Corpus Luteum
Hypothalamus
Vaccination
Antigens

Keywords

  • adjuvants
  • GnRH-I
  • immunocastration
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Siel, Daniela ; Loaiza, Alexandra ; Vidal, Sonia ; Caruffo, Mario ; Paredes, Rodolfo ; Ramirez, Galia ; Lapierre, Lisette ; Briceño, Cristóbal ; Pérez, Oliver ; Sáenz, Leonardo. / The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression. In: American Journal of Reproductive Immunology. 2018 ; Vol. 79, No. 1.
@article{741d4b1a43694647829c88f10098ba74,
title = "The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression",
abstract = "Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.",
keywords = "adjuvants, GnRH-I, immunocastration, vaccine",
author = "Daniela Siel and Alexandra Loaiza and Sonia Vidal and Mario Caruffo and Rodolfo Paredes and Galia Ramirez and Lisette Lapierre and Crist{\'o}bal Brice{\~n}o and Oliver P{\'e}rez and Leonardo S{\'a}enz",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/aji.12772",
language = "English",
volume = "79",
journal = "American Journal of Reproductive Immunology",
issn = "1046-7408",
publisher = "Wiley-Blackwell",
number = "1",

}

The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression. / Siel, Daniela; Loaiza, Alexandra; Vidal, Sonia; Caruffo, Mario; Paredes, Rodolfo; Ramirez, Galia; Lapierre, Lisette; Briceño, Cristóbal; Pérez, Oliver; Sáenz, Leonardo.

In: American Journal of Reproductive Immunology, Vol. 79, No. 1, e12772, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression

AU - Siel, Daniela

AU - Loaiza, Alexandra

AU - Vidal, Sonia

AU - Caruffo, Mario

AU - Paredes, Rodolfo

AU - Ramirez, Galia

AU - Lapierre, Lisette

AU - Briceño, Cristóbal

AU - Pérez, Oliver

AU - Sáenz, Leonardo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

AB - Problem: Immunocastration or vaccination against the GnRH-I hormone is a promising alternative to reproductive control in different animal species. Given the low immunogenicity of this hormone, the use of adjuvants becomes necessary. Method of Study: This study evaluated the effects of three adjuvants that induce different immune response profiles over gonadal function, fertility, and expression of GnRH-I. Female mice (n = 6) were vaccinated at days 1 and 30 with a recombinant antigen for immunocastration and different adjuvants that induced preferentially Th1/Th2, Th2, and Th1 immune profiles. Results: Th1/Th2 response is the most efficient to block reproductive activity in vaccinated animals, reducing the number of luteal bodies and pre-ovulatory follicles. Th2 and Th1/Th2 responses induced an increase in GnRH-I at the hypothalamus. Conclusion: The immune profile induced by different adjuvants is essential on the effects over fertility, gonadal function, and hypothalamic GnRH-I expression in immunocastrated animals.

KW - adjuvants

KW - GnRH-I

KW - immunocastration

KW - vaccine

UR - http://www.scopus.com/inward/record.url?scp=85037706983&partnerID=8YFLogxK

U2 - 10.1111/aji.12772

DO - 10.1111/aji.12772

M3 - Article

AN - SCOPUS:85037706983

VL - 79

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 1046-7408

IS - 1

M1 - e12772

ER -