The Food Environment, Preference, and Experience Modulate the Effects of Exendin-4 on Food Intake and Reward

Ricardo Mella, Camila B. Schmidt, Pierre Paul Romagnoli, Jennifer A. Teske, Claudio Perez-Leighton

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objective: The obesogenic food environment facilitates access to multiple palatable foods. Exendin-4 (EX4) is a glucagon-like peptide 1 receptor (GLP1R) agonist that inhibits food intake and has been proposed as an obesity therapy. This study tested whether the composition of the food environment and experience with palatable foods modulate the effects of EX4 on food intake and reward. Methods: Mice fed a cafeteria (CAF) or control diet were tested for the anorectic effects of EX4 when simultaneously offered foods of varying individual preference and in a conditioned place preference (CPP) test for chocolate. Plasma glucagon-like peptide 1 (GLP1) and hypothalamic GLP1R mRNA were analyzed post mortem. Results: Mice fed a CAF diet developed individual food preference patterns. Offering mice either novel or highly preferred foods decreased the potency of EX4 to inhibit food intake compared to low preference foods or chow. Compared to the control diet, CAF diet intake blocked the decrease in chocolate CPP caused by EX4 and decreased the expression of hypothalamic GLP1R mRNA without altering the plasma GLP1 concentration. Conclusions: The composition of the food environment, food preference, and experience modulate the ability of EX4 to inhibit food intake and reward. These data highlight the significance of modeling the complexity of the human food environment in preclinical obesity studies.

Original languageEnglish
Pages (from-to)1844-1851
Number of pages8
Issue number11
Publication statusPublished - 1 Nov 2017

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


Dive into the research topics of 'The Food Environment, Preference, and Experience Modulate the Effects of Exendin-4 on Food Intake and Reward'. Together they form a unique fingerprint.

Cite this