The essential role of chemokines in the selective regulation of lymphocyte homing

María Rosa Bono, Raúl Elgueta, Daniela Sauma, Karina Pino, Fabiola Osorio, Paula Michea, Alberto Fierro, Mario Rosemblatt

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells is a multiple step process regulated by a specific arrangement of cytokines, chemokines and adhesion receptors that guide these cells to specific locations. Recent research has outlined two major pathways of lymphocyte trafficking under homeostatic and inflammatory conditions, one concerning tropism to cutaneous tissue and a second one related to mucosal-associated sites. In this article we will outline our present understanding of the role of cytokines and chemokines as regulators of lymphocyte migration through tissues.

Original languageEnglish
Pages (from-to)33-43
Number of pages11
JournalCytokine and Growth Factor Reviews
Volume18
Issue number1-2
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Chemokines
  • Lymphocyte homing

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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