The effect of RU486 on transport, development and implantation of mouse embryos

L. S. Roblero, O. Fernández, H. B. Croxatto

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Pregnancy was interrupted in Swiss-Rockefeller mice by a single subcutaneous injection of the antiprogesterone RU486 given postcoitally. A dose of 0.1 mg/animal injected on day 1, produced partial inhibition of pregnancy, a notable delay in embryonic development and a slight retention of embryos in the oviducts. When the same dose was injected on day 2, 3 or 4, no implantation sites were seen at autopsy performed on day 12 of pregnancy. Treatment with 0.5 or 1 mg/animal on day 1 produced the loss of a large proportion of the embryos from the genital tract by day 4 of pregnancy and suppressed implantation completely. These observations indicate that preimplantation phenomena in mice are highly dependent on progesterone action.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalContraception
Volume36
Issue number5
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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