The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium

Coral Pardo-Esté, Alejandro A. Hidalgo, Camila Aguirre, Alan C. Briones, Carolina E. Cabezas, Juan Castro-Severyn, Juan A. Fuentes, Cecilia M. Opazo, Claudia A. Riedel, Carolina Otero, Rodrigo Pacheco, Miguel A. Valvano, Claudia P. Saavedra

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracellularly, S. Typhimurium encounters highly toxic reactive oxygen species including hydrogen peroxide and hypochlorous acid. The molecular mechanisms of Salmonella resistance to intracellular oxidative stress is not completely understood. The ArcAB two-component system is a global regulatory system that responds to oxygen. In this work, we show that the ArcA response regulator participates in Salmonella adaptation to changing oxygen levels and is also involved in promoting intracellular survival in macrophages and neutrophils, enabling S. Typhimurium to successfully establish a systemic infection.

Original languageEnglish
Article numbere0203497
JournalPLoS ONE
Volume13
Issue number9
DOIs
Publication statusPublished - 4 Sep 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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