The analgesic effect of clonixine is not mediated by 5-HT3 subtype receptors

C. Paeile, S. E. Bustamante, F. Sierralta, D. Bustamante, H. F. Miranda

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. The analgesic effect of clonixinate of L-lysine (Clx) in the nociceptive C-fiber reflex in rat and in the writhing test in mice is reported. 2. 2. Clx was administered by three routes, i.v., i.t. and i.c.v., inducing a dose-dependent antinociception. 3. 3. The antinociceptive effect of Clx was 40-45% with respect to the control integration values in the nociceptive C-fiber reflex method. 4. 4. The writhing test yielded ED50 values (mg/kg) of 12.0 ± 1.3 (i.p.), 1.8 ± 0.2 (i.t.) and 0.9 ± 0.1 (i.c.v.) for Clx administration. 5. 5. Ondansetron was not able to antagonize the antinociception response of Clx in the algesiometric tests used. 6. 6. Chlorophenilbiguanide did not produce any significative change in the analgesic effect of Clx in the nociceptive C-fiber reflex method. 7. 7. It is suggested that the mechanism of action of the central analgesia of Clx is not mediated by 5-HT3 subtype receptors.

Original languageEnglish
Pages (from-to)1369-1374
Number of pages6
JournalGeneral Pharmacology
Volume26
Issue number6
DOIs
Publication statusPublished - 1 Jan 1995

Keywords

  • analgesia
  • clonixine
  • Pain
  • serotonin

ASJC Scopus subject areas

  • Pharmacology

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