The 24,000 dalton subunit and the activity of yeast RNA polymerases

Pablo Valenzuela; Graeme I. Bell; William J. Rutter

doi:10.1016/0006-291X(76)90244-8

The 24,000 dalton subunit and the activity of yeast RNA polymerases

Pablo Valenzuela, Graeme I. Bell, William J. Rutter

Life Sciences School

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The subunits of RNA polymerase I are partially resolved during density gradient centrifugation. An analysis of the relative subunit composition with respect to specific catalytic activity shows that the molar ratio of the 24,000 dalton subunit directly correlates with polymerase activity. Since this polypeptide is found also in polymerases II and III, it may be required for activity of all yeast nuclear RNA polymerases.

Original language	English
Pages (from-to)	26-31
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(76)90244-8
Publication status	Published - 12 Jul 1976

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/0006-291X(76)90244-8

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title = "The 24,000 dalton subunit and the activity of yeast RNA polymerases",

abstract = "The subunits of RNA polymerase I are partially resolved during density gradient centrifugation. An analysis of the relative subunit composition with respect to specific catalytic activity shows that the molar ratio of the 24,000 dalton subunit directly correlates with polymerase activity. Since this polypeptide is found also in polymerases II and III, it may be required for activity of all yeast nuclear RNA polymerases.",

author = "Pablo Valenzuela and Bell, {Graeme I.} and Rutter, {William J.}",

year = "1976",

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T1 - The 24,000 dalton subunit and the activity of yeast RNA polymerases

AU - Valenzuela, Pablo

AU - Bell, Graeme I.

AU - Rutter, William J.

PY - 1976/7/12

Y1 - 1976/7/12

N2 - The subunits of RNA polymerase I are partially resolved during density gradient centrifugation. An analysis of the relative subunit composition with respect to specific catalytic activity shows that the molar ratio of the 24,000 dalton subunit directly correlates with polymerase activity. Since this polypeptide is found also in polymerases II and III, it may be required for activity of all yeast nuclear RNA polymerases.

AB - The subunits of RNA polymerase I are partially resolved during density gradient centrifugation. An analysis of the relative subunit composition with respect to specific catalytic activity shows that the molar ratio of the 24,000 dalton subunit directly correlates with polymerase activity. Since this polypeptide is found also in polymerases II and III, it may be required for activity of all yeast nuclear RNA polymerases.

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U2 - 10.1016/0006-291X(76)90244-8

DO - 10.1016/0006-291X(76)90244-8

M3 - Article

C2 - 786283

AN - SCOPUS:0017076829

VL - 71

SP - 26

EP - 31

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -

The 24,000 dalton subunit and the activity of yeast RNA polymerases

Abstract

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