Testosterone and tolerance in rat vas deferens

H. F. Miranda, W. W. Wolstenholme

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalGeneral Pharmacology
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology


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