Testosterone and tolerance in rat vas deferens

H. F. Miranda; W. W. Wolstenholme

doi:10.1016/0306-3623(84)90210-6

Testosterone and tolerance in rat vas deferens

H. F. Miranda, W. W. Wolstenholme

Medicine School

Research output: Contribution to journal › Article › peer-review

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Abstract

1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

Original language	English
Pages (from-to)	529-533
Number of pages	5
Journal	General Pharmacology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/0306-3623(84)90210-6
Publication status	Published - 1984

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(84)90210-6

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title = "Testosterone and tolerance in rat vas deferens",

abstract = "1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.",

author = "Miranda, {H. F.} and Wolstenholme, {W. W.}",

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AB - 1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.

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ER -

Testosterone and tolerance in rat vas deferens

Abstract

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