Targeted nanoparticles for colorectal cancer

Bruno A. Cisterna, Nazila Kamaly, Won Il Choi, Ali Tavakkoli, Omid C. Farokhzad, Cristian Vilos

Research output: Contribution to journalReview articlepeer-review

74 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is highly prevalent worldwide, and despite notable progress in treatment still leads to significant morbidity and mortality. The use of nanoparticles as a drug delivery system has become one of the most promising strategies for cancer therapy. Targeted nanoparticles could take advantage of differentially expressed molecules on the surface of tumor cells, providing effective release of cytotoxic drugs. Several efforts have recently reported the use of diverse molecules as ligands on the surface of nanoparticles to interact with the tumor cells, enabling the effective delivery of antitumor agents. Here, we present recent advances in targeted nanoparticles against CRC and discuss the promising use of ligands and cellular targets in potential strategies for the treatment of CRCs.

Original languageEnglish
Pages (from-to)2443-2456
Number of pages14
JournalNanomedicine
Volume11
Issue number18
DOIs
Publication statusPublished - Sep 2016

Keywords

  • cancer therapy
  • colorectal cancer (CRC)
  • controlled release
  • drug delivery
  • targeted nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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