T-cell homing to the gut mucosa: General concepts and methodological considerations

Jaime De Calisto, Eduardo J. Villablanca, Sen Wang, Maria R. Bono, Mario Rosemblatt, J. Rodrigo Mora

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

14 Citations (Scopus)

Abstract

Effector/memory T cells can migrate to most extra-lymphoid tissues in the body. However, migration to the intestinal mucosa requires the expression of very specific homing receptors on T cells, integrin α4β7 and chemokine receptor CCR9. These receptors are induced by all-trans retinoic acid (RA), a vitamin A metabolite that is specifically synthesized by gut-associated dendritic cells (DC), but not by extra-intestinal DC. Here we summarize some general concepts on T cell homing with an emphasis on the gut mucosa. We also discuss experimental strategies to generate gut-homing T cells in vivo and in vitro and the techniques to track gut-homing T cells.

Original languageEnglish
Title of host publicationIntegrin and Cell Adhesion Molecules
Pages411-434
Number of pages24
Volume757
DOIs
Publication statusPublished - 2011

Publication series

NameMethods in Molecular Biology
Volume757
ISSN (Print)10643745

Keywords

  • α4β7
  • CCL25
  • CCR9
  • Chemotaxis
  • DC
  • GALT
  • Gut homing
  • Homing
  • RALDH
  • Retinoic acid
  • Small intestine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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