9- and 10-membered macrolactones bearing benzo and diazine rings were obtained by chemoselective ozonolysis of dihydrofuran and pyran 1,4-diazaphenathrene derivatives. This is the first example of preparation of macrolactones by chemoselective ozonolysis of an enol double bond shared by aromatic and heterocyclic rings.
- 1,4-Diazaphenanthrene derivatives
- 9- and 10-membered macrolactones
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry