SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE-CHITOSAN NANOBIOPOLYMER COMPOSITE

Rodrigo Ramirez-Tagle, Guillermo Salgado-Moran, David Mendez-Luna, Jose Correa-Basurto, Lorena Gerli Candia, Wilson Cardona Villada, Luis H. Mendoza-Huizar

Research output: Contribution to journalArticlepeer-review

Abstract

A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

Original languageEnglish
Pages (from-to)5063-5066
Number of pages4
JournalJournal of the Chilean Chemical Society
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Amlodipine
  • Chitosan
  • Nanocomposite
  • Drug-release properties
  • Docking studies

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint

Dive into the research topics of 'SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE-CHITOSAN NANOBIOPOLYMER COMPOSITE'. Together they form a unique fingerprint.

Cite this