Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Pablo Valenzuela, Angelica Medina, William J. Rutter, Gustav Ammerer, Benjamin D. Hall

Research output: Contribution to journalArticlepeer-review

577 Citations (Scopus)

Abstract

The surface antigen of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5′-flanking region of yeast alcohol dehydrogenase I as a promoter to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalNature
Volume298
Issue number5872
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Synthesis and assembly of hepatitis B virus surface antigen particles in yeast'. Together they form a unique fingerprint.

Cite this