Synthesis and assembly in yeast of hepatitis b surface antigen particles containing the polyalbumin receptor

Pablo Valenzuela, Doris Coit, Ching H. Kuo

Research output: Contribution to journalLetterpeer-review

37 Citations (Scopus)

Abstract

Yeast cells are genetically engineered to synthesize and assemble hepatitis B surface antigen particles containing 55 additional amino acids encoded by the hepatitis B virus preS gene. These particles are composed of a 28,000 dalton protein and efficiently bind polymerized human albumin. Antibodies to the polyalbumin receptor epitope of this particle may interfere with the postulated polyalbumin-mediated binding of HBV to hepatocytes and may therefore be particularly efficient in preventing the disease.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalBio/Technology
Volume3
Issue number4
DOIs
Publication statusPublished - 1 Jan 1985

ASJC Scopus subject areas

  • Biotechnology

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