Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test

Hugo F. Miranda; Viviana Noriega; Ramiro J. Zepeda; Fernando Sierralta; Juan C. Prieto

doi:10.1007/s10753-011-9420-7

Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test

Hugo F. Miranda, Viviana Noriega, Ramiro J. Zepeda, Fernando Sierralta, Juan C. Prieto

Medicine School

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.

Original language	English
Pages (from-to)	1132-1137
Number of pages	6
Journal	Inflammation
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s10753-011-9420-7
Publication status	Published - Jun 2012

Keywords

Isobolographic analysis, synergism, orofacial formalin test
Opioids
Tonic inflammatory pain

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1007/s10753-011-9420-7

Cite this

@article{d606cab35abc42f294c216977dbe7a54,

title = "Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test",

abstract = "Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.",

keywords = "Isobolographic analysis, synergism, orofacial formalin test, Opioids, Tonic inflammatory pain",

author = "Miranda, {Hugo F.} and Viviana Noriega and Zepeda, {Ramiro J.} and Fernando Sierralta and Prieto, {Juan C.}",

note = "Funding Information: This work was partially supported by project DI-02-11/CB from Universidad Andr{\'e}s Bello. The expert technical assistance of Jose Lopez and Alejandro Correa is gratefully recognized.",

year = "2012",

month = jun,

doi = "10.1007/s10753-011-9420-7",

language = "English",

volume = "35",

pages = "1132--1137",

journal = "Inflammation",

issn = "0360-3997",

publisher = "Springer New York",

number = "3",

}

TY - JOUR

T1 - Synergism between fentanyl and tramadol in tonic inflammatory pain

T2 - The orofacial formalin test

AU - Miranda, Hugo F.

AU - Noriega, Viviana

AU - Zepeda, Ramiro J.

AU - Sierralta, Fernando

AU - Prieto, Juan C.

N1 - Funding Information: This work was partially supported by project DI-02-11/CB from Universidad Andrés Bello. The expert technical assistance of Jose Lopez and Alejandro Correa is gratefully recognized.

PY - 2012/6

Y1 - 2012/6

N2 - Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.

AB - Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED50 of 2.97±0.32 mg/kg for phase I and 1.79±0.30 mg/kg for phase II and 0.062±0.0040 mg/kg in phase I and 0.041±0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.

KW - Isobolographic analysis, synergism, orofacial formalin test

KW - Opioids

KW - Tonic inflammatory pain

UR - http://www.scopus.com/inward/record.url?scp=84863788265&partnerID=8YFLogxK

U2 - 10.1007/s10753-011-9420-7

DO - 10.1007/s10753-011-9420-7

M3 - Article

C2 - 22198345

AN - SCOPUS:84863788265

SN - 0360-3997

VL - 35

SP - 1132

EP - 1137

JO - Inflammation

JF - Inflammation

IS - 3

ER -

Synergism between fentanyl and tramadol in tonic inflammatory pain: The orofacial formalin test

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this