Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells

Daniela A. Geraldo, Esteban F. Duran-Lara, Daniel Aguayo, Raul E. Cachau, Jaime Tapia, Rodrigo Esparza, Miguel J. Yacaman, Fernando Danilo Gonzalez-Nilo, Leonardo S. Santos

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.

Original languageEnglish
Pages (from-to)483-492
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Volume400
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Gastric cancer cells
  • Molecular dynamics (MD) simulations
  • PAMAM dendrimers
  • Quantum dots
  • Supramolecular complexes
  • Transmission electron microscopy (TEM)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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