Study of blood coagulation in women treated with megestrol acetate implants

Blood coagulation tests done in 38 women bearing subdermal implants of megestrol acetate as a contraceptive after 14 to 43 months continuous treatment. A group of 12 untreated women of similar age and parity was used as control. Platelet count, clotting time, prothrombin time, partial thromboplastin time, prothrombin consumption test, thromboplastin generation time, euglobulin lysis time, fibrinogen, factors II, V, VII-X, X and VIII, and platelet adhesiveness were determined during the follicular phase of the cycle. All tests showed normal values and no significant differences were found between the groups. It was concluded that continuous, systemic and long-term administration of megestrol acetate does not lead to blood coagulation disorders.