Structural antitumoral activity relationships of synthetic chalcones

Cesar Echeverria, Juan Francisco Santibañez, Oscar Donoso-Tauda, Carlos A. Escobar, Rodrigo Ramirez-Tagle

Research output: Contribution to journalArticlepeer-review

120 Citations (Scopus)

Abstract

Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Antitumoral activity
  • DFT
  • Structure-activity relationships

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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