Spin trapping: An essential tool for the study of diseases caused by oxidative stress

Germán Barriga-González, Claudio Olea-Azar, María C. Zuñiga-López, Christian Folch-Cano, Benjamín Aguilera-Venegas, Williams Porcal, Mercedes González, Hugo Cerecetto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Electron spin resonance (ESR), called also electron paramagnetic resonance (EPR) together with the spin trapping technique, has allowed us to study and understand how free radicals are involved in various pathologies. In this review, the importance of spin trapping technique in the study of diseases such as cancer, diabetes, hypertension and parasitic diseases is discussed. In addition, advances in the use of this technique as therapeutic agents and other interesting applications as the immuno-spin trapping technique are reviewed.

Original languageEnglish
Pages (from-to)484-495
Number of pages12
JournalCurrent Topics in Medicinal Chemistry
Volume15
Issue number5
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • DMPO
  • EPR
  • ESR
  • Human diseases
  • Immuno-spin trapping
  • Oxidative stress
  • PBN
  • Spin traps

ASJC Scopus subject areas

  • Drug Discovery
  • Medicine(all)

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