Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis

Juan Salazar, Daniela Pirela, Manuel Nava, Ana Castro, Lissé Angarita, Heliana Parra, Samuel Durán-Agüero, Diana Marcela Rojas-Gómez, Néstor Galbán, Roberto Añez, Maricarmen Chacín, Andrea Diaz, Nelson Villasmil, Juan Bautista De Sanctis, Valmore Bermúdez

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Cardiovascular disease (CVD) is a global public health issue due to its high morbidity, mortality, and economic impact. The implementation of innovative therapeutic alternatives for CVD is urgently required. Specialized proresolving lipid mediators (SPMs) are bioactive compounds derived from ω-3 and ω-6 fatty acids, integrated into four families: Lipoxins, Resolvins, Protectins, and Maresins. SPMs have generated interest in recent years due to their ability to promote the resolution of inflammation associated with the pathogeneses of numerous illnesses, particularly CVD. Several preclinical studies in animal models have evidenced their ability to decrease the progression of atherosclerosis, intimal hyperplasia, and reperfusion injury via diverse mechanisms. Large-scale clinical trials are required to determine the effects of SPMs in humans. This review integrates the currently available knowledge of the therapeutic impact of SPMs in CVD from preclinical and clinical studies, along with the implicated molecular pathways. In vitro results have been promising, and as such, SPMs could soon represent a new therapeutic alternative for CVD.

Original languageEnglish
Article number3133
JournalInternational Journal of Molecular Sciences
Volume23
Issue number6
DOIs
Publication statusPublished - 1 Mar 2022

Keywords

  • Atherosclerosis
  • Inflammation
  • Intimal hyperplasia
  • Reperfusion injury
  • Resolution
  • Specialized proresolving mediators

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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