Sistema de flujo continuo no segmentado con deteccion polarografica para la determinacion de ranitidina en formas farmaceuticas y orina

Pablo Jaque-Olmedo, M. Ines Toral, Pablo Richter

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2 Citations (Scopus)

Abstract

In this work we developed a method by flow injection analysis for the determination of ranitidine in pharmaceutical forms and urine, using a polarographic flow through cell as detection system which has been designed recently in our laboratory. The method is based on the reduction of the group nitro of the drug to the hydroxylamine derivative by applying a potential of -1.40 V vs mercury pool electrode. It was found a determination range of 2.38×10 -5 -1.0×10 -3 M ranitidine, with a detection limit of 7.15×10 -6 M. The relative standard deviation (n = 11) for a concentration level of 1.0×10 -4 M was 2.1%, which is comparable with the obtained, by the manual methodology. The accuracy of the method was evaluated by comparison of the results with those obtained by d.c. polarography and UV spectrophotometry and the results were quite comparable.

Original languageSpanish
Pages (from-to)45-53
Number of pages9
JournalBoletin de la Sociedad Chilena de Quimica
Volume43
Issue number1
Publication statusPublished - 1 Dec 1998

ASJC Scopus subject areas

  • Chemistry(all)

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