Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry

M. Inés Toral, Pablo Richter, Nelson Lara, Pablo Jaque, Cesar Soto, Marcela Saavedra

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. Acetonitrile was used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of the drugs can be carried out using the zero-crossing method for clidinium bromide at 220.8 nm and the graphical method for chlordiazepoxide at 283.6 nm. The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/l of clidinium bromide and from 0.740 to 12.0 mg/l of chlordiazepoxide. The ingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determination of these drugs in tablets. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume189
Issue number1
DOIs
Publication statusPublished - 28 Oct 1999

Keywords

  • Chlordiazepoxide
  • Clidinium bromide
  • First derivative spectrophotometry
  • Pharmaceutical formulations
  • Simultaneous determination

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry'. Together they form a unique fingerprint.

Cite this