Seasonal environmental changes modulate the prolactin receptor expression in an eurythermal fish

Rody San Martín, Pilar Cáceres, Rodrigo Azócar, Marco Alvarez, Alfredo Molina, María I. Vera, Manuel Krauskopf

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Eurythermal fish have evolved compensatory responses to the cyclical seasonal changes of the environment. The complex adaptive mechanisms include the transduction of the physical parameters variations into molecular signals. Studies in carp have indicated that prolactin and growth hormone expression is associated with acclimatization, suggesting that the pituitary gland is a relevant physiological node in the generation of the homeostatic rearrangement that occurs in this adaptive process. Here, we report the cloning and characterization of a full-length carp prolactin receptor cDNA, which codes for the long form of the protein resembling that found in mammalian prolactin receptors. We identified up to three receptor transcript isoforms in different tissues of the teleost and assessed cell- and temporal-specific transcription and protein expression in carp undergoing seasonal acclimatization. The distinctive pattern of expression that carp prolactin receptor (cPRLr) depicts upon seasonal acclimatization supports the hypothesis that prolactin and its receptor are clearly involved in the new homeostatic stage that the eurythermal fish needs to survive during the cyclical changes of its habitat.

Original languageEnglish
Pages (from-to)42-52
Number of pages11
JournalJournal of Cellular Biochemistry
Issue number1
Publication statusPublished - 1 Dec 2004


  • Acclimatization
  • Prolactin receptor
  • Teleost

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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