Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration

Franco Tacchi; Josué Orozco-Aguilar; Danae Gutiérrez; Felipe Simon; Javier Salazar; Cristian Vilos; Claudio Cabello-Verrugio

doi:10.2217/nnm-2021-0224

Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration

Franco Tacchi, Josué Orozco-Aguilar, Danae Gutiérrez, Felipe Simon, Javier Salazar, Cristian Vilos, Claudio Cabello-Verrugio

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Skeletal muscle is integral to the functioning of the human body. Several pathological conditions, such as trauma (primary lesion) or genetic diseases such as Duchenne muscular dystrophy (DMD), can affect and impair its functions or exceed its regeneration capacity. Tissue engineering (TE) based on natural, synthetic and hybrid biomaterials provides a robust platform for developing scaffolds that promote skeletal muscle regeneration, strength recovery, vascularization and innervation. Recent 3D-cell printing technology and the use of nanocarriers for the release of drugs, peptides and antisense oligonucleotides support unique therapeutic alternatives. Here, the authors present recent advances in scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration and perspectives for future endeavors.

Original language	English
Pages (from-to)	2521-2538
Number of pages	18
Journal	Nanomedicine
Volume	16
Issue number	28
DOIs	https://doi.org/10.2217/nnm-2021-0224
Publication status	Published - Dec 2021

Keywords

muscle wasting
nanocarriers
tissue engineering
volumetric muscle loss

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2021-0224

Cite this

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abstract = "Skeletal muscle is integral to the functioning of the human body. Several pathological conditions, such as trauma (primary lesion) or genetic diseases such as Duchenne muscular dystrophy (DMD), can affect and impair its functions or exceed its regeneration capacity. Tissue engineering (TE) based on natural, synthetic and hybrid biomaterials provides a robust platform for developing scaffolds that promote skeletal muscle regeneration, strength recovery, vascularization and innervation. Recent 3D-cell printing technology and the use of nanocarriers for the release of drugs, peptides and antisense oligonucleotides support unique therapeutic alternatives. Here, the authors present recent advances in scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration and perspectives for future endeavors. ",

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T1 - Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration

AU - Tacchi, Franco

AU - Orozco-Aguilar, Josué

AU - Gutiérrez, Danae

AU - Simon, Felipe

AU - Salazar, Javier

AU - Vilos, Cristian

AU - Cabello-Verrugio, Claudio

PY - 2021/12

Y1 - 2021/12

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AB - Skeletal muscle is integral to the functioning of the human body. Several pathological conditions, such as trauma (primary lesion) or genetic diseases such as Duchenne muscular dystrophy (DMD), can affect and impair its functions or exceed its regeneration capacity. Tissue engineering (TE) based on natural, synthetic and hybrid biomaterials provides a robust platform for developing scaffolds that promote skeletal muscle regeneration, strength recovery, vascularization and innervation. Recent 3D-cell printing technology and the use of nanocarriers for the release of drugs, peptides and antisense oligonucleotides support unique therapeutic alternatives. Here, the authors present recent advances in scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration and perspectives for future endeavors.

KW - muscle wasting

KW - nanocarriers

KW - tissue engineering

KW - volumetric muscle loss

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U2 - 10.2217/nnm-2021-0224

DO - 10.2217/nnm-2021-0224

M3 - Review article

AN - SCOPUS:85120701724

SN - 1743-5889

VL - 16

SP - 2521

EP - 2538

JO - Nanomedicine

JF - Nanomedicine

IS - 28

ER -

Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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