Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration

Franco Tacchi, Josué Orozco-Aguilar, Danae Gutiérrez, Felipe Simon, Javier Salazar, Cristian Vilos, Claudio Cabello-Verrugio

Research output: Contribution to journalReview articlepeer-review

Abstract

Skeletal muscle is integral to the functioning of the human body. Several pathological conditions, such as trauma (primary lesion) or genetic diseases such as Duchenne muscular dystrophy (DMD), can affect and impair its functions or exceed its regeneration capacity. Tissue engineering (TE) based on natural, synthetic and hybrid biomaterials provides a robust platform for developing scaffolds that promote skeletal muscle regeneration, strength recovery, vascularization and innervation. Recent 3D-cell printing technology and the use of nanocarriers for the release of drugs, peptides and antisense oligonucleotides support unique therapeutic alternatives. Here, the authors present recent advances in scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration and perspectives for future endeavors.

Original languageEnglish
Pages (from-to)2521-2538
Number of pages18
JournalNanomedicine
Volume16
Issue number28
DOIs
Publication statusPublished - Dec 2021

Keywords

  • muscle wasting
  • nanocarriers
  • tissue engineering
  • volumetric muscle loss

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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