Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional

Translated title of the contribution: Metabolic Syndrome. Clinical and pathophysiological basis for a rational therapeutical approach

Gonzalo Martínez R, Rodrigo Alonso K, Victoria Novik A

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistance of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, that inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferator-activated receptors (PPAR) seems promising.

Translated title of the contributionMetabolic Syndrome. Clinical and pathophysiological basis for a rational therapeutical approach
Original languageSpanish
Pages (from-to)685-694
Number of pages10
JournalRevista Medica de Chile
Volume137
Issue number5
Publication statusPublished - 1 May 2009

ASJC Scopus subject areas

  • Medicine(all)

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