Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein; Jane B. Lian; Andre J. Van Wijnen; Janet L. Stein; Martin Montecino; Amjad Javed; Sayyed K. Zaidi; Daniel W. Young; Je Yong Choi; Shirwin M. Pockwinse

doi:10.1038/sj.onc.1207676

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Martin Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Shirwin M. Pockwinse

Life Sciences School

Research output: Contribution to journal › Review article › peer-review

451 Citations (Scopus)

Abstract

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

Original language	English
Pages (from-to)	4315-4329
Number of pages	15
Journal	Oncogene
Volume	23
Issue number	24
DOIs	https://doi.org/10.1038/sj.onc.1207676
Publication status	Published - 24 May 2004

Keywords

Chromatin modifications
Gene expression
Nuclear architecture
Osteoblast
Runx/AML/Cbfa

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/sj.onc.1207676

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title = "Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression",

abstract = "We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.",

keywords = "Chromatin modifications, Gene expression, Nuclear architecture, Osteoblast, Runx/AML/Cbfa",

author = "Stein, {Gary S.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Stein, {Janet L.} and Martin Montecino and Amjad Javed and Zaidi, {Sayyed K.} and Young, {Daniel W.} and Choi, {Je Yong} and Pockwinse, {Shirwin M.}",

note = "Funding Information: Results presented in this paper were in part supported by grants for the National Institutes of Health (AR45688, PO1CA82834, DE12528, AR39588, AR45689, PO1AR48818, FIRCA R03 TW00990, FONDECYT 1030479). We appreciate the editorial assistance of Elizabeth Bronstein with the preparation of this paper.",

year = "2004",

month = may,

day = "24",

doi = "10.1038/sj.onc.1207676",

language = "English",

volume = "23",

pages = "4315--4329",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "24",

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TY - JOUR

T1 - Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

AU - Stein, Gary S.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Stein, Janet L.

AU - Montecino, Martin

AU - Javed, Amjad

AU - Zaidi, Sayyed K.

AU - Young, Daniel W.

AU - Choi, Je Yong

AU - Pockwinse, Shirwin M.

N1 - Funding Information: Results presented in this paper were in part supported by grants for the National Institutes of Health (AR45688, PO1CA82834, DE12528, AR39588, AR45689, PO1AR48818, FIRCA R03 TW00990, FONDECYT 1030479). We appreciate the editorial assistance of Elizabeth Bronstein with the preparation of this paper.

PY - 2004/5/24

Y1 - 2004/5/24

N2 - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

AB - We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

KW - Chromatin modifications

KW - Gene expression

KW - Nuclear architecture

KW - Osteoblast

KW - Runx/AML/Cbfa

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U2 - 10.1038/sj.onc.1207676

DO - 10.1038/sj.onc.1207676

M3 - Review article

C2 - 15156188

AN - SCOPUS:2942548981

SN - 0950-9232

VL - 23

SP - 4315

EP - 4329

JO - Oncogene

JF - Oncogene

IS - 24

ER -

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Abstract

Keywords

ASJC Scopus subject areas

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