Role of orexin receptors in obesity: From cellular to behavioral evidence

C. E. Perez-Leighton, T. A. Butterick-Peterson, C. J. Billington, C. M. Kotz

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


The orexin peptides and their two receptors are involved in multiple physiological processes, including energy homeostasis, arousal, stress and reward. Higher signaling of the orexin peptides at the orexin receptors (OXR) protects against obesity, but it is less clear how their activation in different brain regions contributes to this behavioral output. This review summarizes the evidence available for a role of central OXR in energy homeostasis and their contribution to obesity. A detailed analysis of anatomical, cellular and behavioral evidence shows that modulation of energy homeostasis by the OXR is largely dependent upon anatomical and cellular context. It also shows that obesity resistance provided by activation of the OXR is distributed across multiple brain sites with site-specific actions. We suggest that understanding the role of the OXR in the development of obesity requires considering both specific mechanisms within brain regions and interactions of orexinergic input between multiple sites.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalInternational Journal of Obesity
Issue number2
Publication statusPublished - Feb 2013


  • diet-induced obesity
  • energy metabolism
  • hypothalamus
  • orexin
  • orexin receptors
  • spontaneous physical activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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