Role of dopamine in the physiology of T-cells and dendritic cells

Rodrigo Pacheco, Carolina E. Prado, Magaly J. Barrientos, Sebastián Bernales

Research output: Contribution to journalReview articlepeer-review

95 Citations (Scopus)

Abstract

Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DC and T-cell physiology and, in turn, immune response. Moreover, we discuss how alterations in the dopamine-mediated immune regulatory mechanisms could contribute to the onset of immune-related disorders.

Original languageEnglish
Pages (from-to)8-19
Number of pages12
JournalJournal of Neuroimmunology
Volume216
Issue number1-2
DOIs
Publication statusPublished - 30 Nov 2009

Keywords

  • CD4+ helper T-cells
  • CD8+ cytotoxic T-cells
  • Dendritic cells
  • Dopamine
  • T-cell mediated immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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