Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases

Juan Pablo Mackern-Oberti, Carolina Llanos, Fabián Vega, Flavio Salazar-Onfray, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)

Abstract

Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory receptors expressed on the surface of DCs has been linked to increased susceptibility to develop autoimmune diseases underscoring their immunogenicity potential. It has been described that modulation of activating or inhibitory molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcγRs, can define the immunogenic phenotype. On the other hand, T cell tolerance can be achieved by tolerogenic DCs, which have the capacity of blocking undesired autoimmune responses in several experimental models, mainly by inducing T cell anergy, expansion of regulatory T cells and limiting B cell responses. Due to the lack of specific therapies to treat autoimmune disorders and the tolerogenic capacity of DCs shown in experimental autoimmune disease models, autologous tolDCs are a potential therapeutic strategy for fine-tuning the immune system and reestablishing tolerance in human autoimmune diseases. New advances in the role of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification of pathogenic self-Ags may favor the development of novel tolDC based therapies with a major clinical impact. In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to restore tolerance.

Original languageEnglish
Pages (from-to)127-139
Number of pages13
JournalAutoimmunity Reviews
Volume14
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Dendritic cells
  • Immune tolerance
  • Immunotherapy
  • Lupus
  • Systemic autoimmunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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