TY - JOUR
T1 - Role of astroglial hemichannels and pannexons in memory and neurodegenerative diseases
AU - Orellana, Juan A.
AU - Retamal, Mauricio A.
AU - Moraga-Amaro, Rodrigo
AU - Stehberg, Jimmy
N1 - Funding Information:
This work was supported by grants FONDECYT 11121133 (JAO), 1160710 (JAO), 1120214 (MAR) and 1160986 (JS); UNAB DI-603-14/N (JS), CORFO 14IDL2-30195 (JS); CAEN from the ISFN (JAO), and CONICYT ACT 1104 (MAR) and ACT 1411 (JAO). We wish to thank Kathleen McBennett for her contributions.
Publisher Copyright:
© 2016 Orellana, Retamal, Moraga-Amaro and Stehberg.
PY - 2016/7/20
Y1 - 2016/7/20
N2 - Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases.
AB - Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases.
KW - Astrocytes
KW - Connexin 43
KW - Connexin hemichannels
KW - Cx hemichannels
KW - Memory
KW - Pannexin
UR - http://www.scopus.com/inward/record.url?scp=84995663879&partnerID=8YFLogxK
U2 - 10.3389/fnint.2016.00026
DO - 10.3389/fnint.2016.00026
M3 - Article
AN - SCOPUS:84995663879
SN - 1662-5145
VL - 10
JO - Frontiers in Integrative Neuroscience
JF - Frontiers in Integrative Neuroscience
IS - JULY2016
M1 - 26
ER -