Risk factors and pathogenesis of cholesterol gallstones: State of the art

L. Amigo, S. Zanlungo, H. Mendoza, J. F. Miquel, F. Nervi

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


The aim of this article is to present an update of selected aspects of the pathogenesis and risk factors of cholesterol gallstones, a highly prevalent Western disease. The etiology of cholesterol cholelithiasis is considered to be multifactorial, with interaction of genetic and environmental factors. Mechanisms of cholesterol lithogenesis include biliary cholesterol hypersecretion, supersaturation and crystallization, stone formation and growth, and bile stasis within the gallbladder. Each of these various steps could be under genetic control and/or be influenced through intermediate pathogenic steps linked to a variety of environmental factors.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalEuropean Review for Medical and Pharmacological Sciences
Issue number6
Publication statusPublished - 1999


  • Etiology
  • Gallstones
  • Pathophysiolog
  • Risk factors

ASJC Scopus subject areas

  • Pharmacology


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