Ric-8: Different cellular roles for a heterotrimeric G-protein GEF

M. V. Hinrichs, M. Torrejón, M. Montecino, J. Olate

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Signaling via heterotrimeric G-proteins is evoked by agonist-mediated stimulation of seven transmembrane spanning receptors (GPCRs). During the last decade it has become apparent that Gα subunits can be activated by receptor-independent mechanisms. Ric-8 belongs to a highly conserved protein family that regulates heterotrimeric G-protein function, acting as a non-canonical guanine nucleotide exchange factors (GEF) over a subset of Gα subunits. In this review we discuss the roles of Ric-8 in the regulation of diverse cell functions, emphasizing the contribution of its multiple domain protein structure in these diverse functions.

Original languageEnglish
Pages (from-to)2797-2805
Number of pages9
JournalJournal of Cellular Biochemistry
Volume113
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • G-protein
  • GEF
  • Ric-8
  • signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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