Response to intermittent RU486 in women

I. M. Spitz; H. B. Croxatto; A. M. Salvatierra; O. Heikinheimo

doi:10.1016/s0015-0282(16)55912-3

Response to intermittent RU486 in women

I. M. Spitz, H. B. Croxatto, A. M. Salvatierra, O. Heikinheimo

Medicine School

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Objective: To determine the effects of intermittent administration of the antiprogestin RU486 on ovarian function. Design: Three different regimens of RU486 were tested. Participants: Nine healthy regularly menstruating volunteers protected by an intrauterine device or surgical sterilization. Interventions: Two groups of three women each received 10 mg or 50 mg RU486 at weekly intervals for 5 weeks. Another three women received 50 mg RU486 for 3 consecutive days at 10-day intervals for 80 days. Main Outcome Measures: Serum E₂, P, and RU486 levels. Ovarian ultrasound (US) and serum LH and FSH in select subjects. Results: The predominant effect was partial inhibition of E₂ secretion and suppressed P levels. During a total aggregate of 16 treatment months, there were seven episodes of elevated P levels; however, US did not always indicate the occurrence of normal ovulation. Conclusion: Intermittent RU486 administration can interfere with normal follicular development and function, but its clinical application may require a more effective dose and/or timing of administration.

Original language	English
Pages (from-to)	971-975
Number of pages	5
Journal	Fertility and Sterility
Volume	59
Issue number	5
DOIs	https://doi.org/10.1016/s0015-0282(16)55912-3
Publication status	Published - 1993

Keywords

E and P responses
RU486
follicular development
intermittent administration
mifepristone
ultrasonography

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

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10.1016/s0015-0282(16)55912-3

Cite this

@article{005474d4276145259884e478ce744784,

title = "Response to intermittent RU486 in women",

abstract = "Objective: To determine the effects of intermittent administration of the antiprogestin RU486 on ovarian function. Design: Three different regimens of RU486 were tested. Participants: Nine healthy regularly menstruating volunteers protected by an intrauterine device or surgical sterilization. Interventions: Two groups of three women each received 10 mg or 50 mg RU486 at weekly intervals for 5 weeks. Another three women received 50 mg RU486 for 3 consecutive days at 10-day intervals for 80 days. Main Outcome Measures: Serum E2, P, and RU486 levels. Ovarian ultrasound (US) and serum LH and FSH in select subjects. Results: The predominant effect was partial inhibition of E2 secretion and suppressed P levels. During a total aggregate of 16 treatment months, there were seven episodes of elevated P levels; however, US did not always indicate the occurrence of normal ovulation. Conclusion: Intermittent RU486 administration can interfere with normal follicular development and function, but its clinical application may require a more effective dose and/or timing of administration.",

keywords = "E and P responses, RU486, follicular development, intermittent administration, mifepristone, ultrasonography",

author = "Spitz, {I. M.} and Croxatto, {H. B.} and Salvatierra, {A. M.} and O. Heikinheimo",

note = "Funding Information: Received July 30, 1992; revised and accepted January 7, 1993. * RU486 (mifepristone) Roussel UCLAF, Paris, France. t Supported in part by The George J. Hecht Fund, The Andrew F. Mellon Foundation and the Rockefeller Foundation, New York, New York, and the Fondo Nacional de Investigacion Cientifica y Tecnologica (grant 90-0818) Providencia, Santiago, Chile. t Presented at Terra Symposia III, Progesterone Antagonists, New Paltz, New York, May 25 to 29, 1992. § Reprint requests: Irving M. Spitz, M.D., Center for Biomedical Research, The Population Council, 1230 York Avenue, New York, New York 10021. II lnstituto Chileno de Medicina Reproductiva, Jose Ramon Gutierrez 295, Depto 1. 11 Department of Medical Chemistry, Steroid Research Laboratory, University of Helsinki.",

year = "1993",

doi = "10.1016/s0015-0282(16)55912-3",

language = "English",

volume = "59",

pages = "971--975",

journal = "Fertility and Sterility",

issn = "0015-0282",

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TY - JOUR

T1 - Response to intermittent RU486 in women

AU - Spitz, I. M.

AU - Croxatto, H. B.

AU - Salvatierra, A. M.

AU - Heikinheimo, O.

N1 - Funding Information: Received July 30, 1992; revised and accepted January 7, 1993. * RU486 (mifepristone) Roussel UCLAF, Paris, France. t Supported in part by The George J. Hecht Fund, The Andrew F. Mellon Foundation and the Rockefeller Foundation, New York, New York, and the Fondo Nacional de Investigacion Cientifica y Tecnologica (grant 90-0818) Providencia, Santiago, Chile. t Presented at Terra Symposia III, Progesterone Antagonists, New Paltz, New York, May 25 to 29, 1992. § Reprint requests: Irving M. Spitz, M.D., Center for Biomedical Research, The Population Council, 1230 York Avenue, New York, New York 10021. II lnstituto Chileno de Medicina Reproductiva, Jose Ramon Gutierrez 295, Depto 1. 11 Department of Medical Chemistry, Steroid Research Laboratory, University of Helsinki.

PY - 1993

Y1 - 1993

N2 - Objective: To determine the effects of intermittent administration of the antiprogestin RU486 on ovarian function. Design: Three different regimens of RU486 were tested. Participants: Nine healthy regularly menstruating volunteers protected by an intrauterine device or surgical sterilization. Interventions: Two groups of three women each received 10 mg or 50 mg RU486 at weekly intervals for 5 weeks. Another three women received 50 mg RU486 for 3 consecutive days at 10-day intervals for 80 days. Main Outcome Measures: Serum E2, P, and RU486 levels. Ovarian ultrasound (US) and serum LH and FSH in select subjects. Results: The predominant effect was partial inhibition of E2 secretion and suppressed P levels. During a total aggregate of 16 treatment months, there were seven episodes of elevated P levels; however, US did not always indicate the occurrence of normal ovulation. Conclusion: Intermittent RU486 administration can interfere with normal follicular development and function, but its clinical application may require a more effective dose and/or timing of administration.

AB - Objective: To determine the effects of intermittent administration of the antiprogestin RU486 on ovarian function. Design: Three different regimens of RU486 were tested. Participants: Nine healthy regularly menstruating volunteers protected by an intrauterine device or surgical sterilization. Interventions: Two groups of three women each received 10 mg or 50 mg RU486 at weekly intervals for 5 weeks. Another three women received 50 mg RU486 for 3 consecutive days at 10-day intervals for 80 days. Main Outcome Measures: Serum E2, P, and RU486 levels. Ovarian ultrasound (US) and serum LH and FSH in select subjects. Results: The predominant effect was partial inhibition of E2 secretion and suppressed P levels. During a total aggregate of 16 treatment months, there were seven episodes of elevated P levels; however, US did not always indicate the occurrence of normal ovulation. Conclusion: Intermittent RU486 administration can interfere with normal follicular development and function, but its clinical application may require a more effective dose and/or timing of administration.

KW - E and P responses

KW - RU486

KW - follicular development

KW - intermittent administration

KW - mifepristone

KW - ultrasonography

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AN - SCOPUS:0027270157

SN - 0015-0282

VL - 59

SP - 971

EP - 975

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -

Response to intermittent RU486 in women

Abstract

Keywords

ASJC Scopus subject areas

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