Response to intermittent RU486 in women

I. M. Spitz, H. B. Croxatto, A. M. Salvatierra, O. Heikinheimo

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Objective: To determine the effects of intermittent administration of the antiprogestin RU486 on ovarian function. Design: Three different regimens of RU486 were tested. Participants: Nine healthy regularly menstruating volunteers protected by an intrauterine device or surgical sterilization. Interventions: Two groups of three women each received 10 mg or 50 mg RU486 at weekly intervals for 5 weeks. Another three women received 50 mg RU486 for 3 consecutive days at 10-day intervals for 80 days. Main Outcome Measures: Serum E2, P, and RU486 levels. Ovarian ultrasound (US) and serum LH and FSH in select subjects. Results: The predominant effect was partial inhibition of E2 secretion and suppressed P levels. During a total aggregate of 16 treatment months, there were seven episodes of elevated P levels; however, US did not always indicate the occurrence of normal ovulation. Conclusion: Intermittent RU486 administration can interfere with normal follicular development and function, but its clinical application may require a more effective dose and/or timing of administration.

Original languageEnglish
Pages (from-to)971-975
Number of pages5
JournalFertility and Sterility
Volume59
Issue number5
Publication statusPublished - 1 Jan 1993

Keywords

  • E and P responses
  • follicular development
  • intermittent administration
  • mifepristone
  • RU486
  • ultrasonography

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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