Recent Asian origin of chytrid fungi causing global amphibian declines

Simon J. O’Hanlon; Adrien Rieux; Rhys A. Farrer; Gonçalo M. Rosa; Bruce Waldman; Arnaud Bataille; Tiffany A. Kosch; Kris A. Murray; Balázs Brankovics; Matteo Fumagalli; Michael D. Martin; Nathan Wales; Mario Alvarado-Rybak; Kieran A. Bates; Lee Berger; Susanne Böll; Lola Brookes; Frances Clare; Elodie A. Courtois; Andrew A. Cunningham; Thomas M. Doherty-Bone; Pria Ghosh; David J. Gower; William E. Hintz; Jacob Höglund; Thomas S. Jenkinson; Chun Fu Lin; Anssi Laurila; Adeline Loyau; An Martel; Sara Meurling; Claude Miaud; Pete Minting; Frank Pasmans; Dirk S. Schmeller; Benedikt R. Schmidt; Jennifer M.G. Shelton; Lee F. Skerratt; Freya Smith; Claudio Soto-Azat; Matteo Spagnoletti; Giulia Tessa; Luís Felipe Toledo; Andrés Valenzuela-Sánchez; Ruhan Verster; Judit Vörös; Rebecca J. Webb; Claudia Wierzbicki; Emma Wombwell; Kelly R. Zamudio

doi:10.1126/science.aar1965

Recent Asian origin of chytrid fungi causing global amphibian declines

Simon J. O’Hanlon, Adrien Rieux, Rhys A. Farrer, Gonçalo M. Rosa, Bruce Waldman, Arnaud Bataille, Tiffany A. Kosch, Kris A. Murray, Balázs Brankovics, Matteo Fumagalli, Michael D. Martin, Nathan Wales, Mario Alvarado-Rybak, Kieran A. Bates, Lee Berger, Susanne Böll, Lola Brookes, Frances Clare, Elodie A. Courtois, Andrew A. CunninghamThomas M. Doherty-Bone, Pria Ghosh, David J. Gower, William E. Hintz, Jacob Höglund, Thomas S. Jenkinson, Chun Fu Lin, Anssi Laurila, Adeline Loyau, An Martel, Sara Meurling, Claude Miaud, Pete Minting, Frank Pasmans, Dirk S. Schmeller, Benedikt R. Schmidt, Jennifer M.G. Shelton, Lee F. Skerratt, Freya Smith, Claudio Soto-Azat, Matteo Spagnoletti, Giulia Tessa, Luís Felipe Toledo, Andrés Valenzuela-Sánchez, Ruhan Verster, Judit Vörös, Rebecca J. Webb, Claudia Wierzbicki, Emma Wombwell, Kelly R. Zamudio

Life Sciences School

Research output: Contribution to journal › Article › peer-review

380 Citations (Scopus)

Abstract

Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.

Original language	English
Pages (from-to)	621-627
Number of pages	7
Journal	Science
Volume	360
Issue number	6389
DOIs	https://doi.org/10.1126/science.aar1965
Publication status	Published - 11 May 2018

ASJC Scopus subject areas

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UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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O’Hanlon, S. J., Rieux, A., Farrer, R. A., Rosa, G. M., Waldman, B., Bataille, A., Kosch, T. A., Murray, K. A., Brankovics, B., Fumagalli, M., Martin, M. D., Wales, N., Alvarado-Rybak, M., Bates, K. A., Berger, L., Böll, S., Brookes, L., Clare, F., Courtois, E. A., ... Zamudio, K. R. (2018). Recent Asian origin of chytrid fungi causing global amphibian declines. Science, 360(6389), 621-627. https://doi.org/10.1126/science.aar1965

@article{a164d07a55244fbea405a27ef9a10ff7,

title = "Recent Asian origin of chytrid fungi causing global amphibian declines",

abstract = "Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.",

author = "O{\textquoteright}Hanlon, {Simon J.} and Adrien Rieux and Farrer, {Rhys A.} and Rosa, {Gon{\c c}alo M.} and Bruce Waldman and Arnaud Bataille and Kosch, {Tiffany A.} and Murray, {Kris A.} and Bal{\'a}zs Brankovics and Matteo Fumagalli and Martin, {Michael D.} and Nathan Wales and Mario Alvarado-Rybak and Bates, {Kieran A.} and Lee Berger and Susanne B{\"o}ll and Lola Brookes and Frances Clare and Courtois, {Elodie A.} and Cunningham, {Andrew A.} and Doherty-Bone, {Thomas M.} and Pria Ghosh and Gower, {David J.} and Hintz, {William E.} and Jacob H{\"o}glund and Jenkinson, {Thomas S.} and Lin, {Chun Fu} and Anssi Laurila and Adeline Loyau and An Martel and Sara Meurling and Claude Miaud and Pete Minting and Frank Pasmans and Schmeller, {Dirk S.} and Schmidt, {Benedikt R.} and Shelton, {Jennifer M.G.} and Skerratt, {Lee F.} and Freya Smith and Claudio Soto-Azat and Matteo Spagnoletti and Giulia Tessa and Toledo, {Lu{\'i}s Felipe} and Andr{\'e}s Valenzuela-S{\'a}nchez and Ruhan Verster and Judit V{\"o}r{\"o}s and Webb, {Rebecca J.} and Claudia Wierzbicki and Emma Wombwell and Zamudio, {Kelly R.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.",

year = "2018",

month = may,

day = "11",

doi = "10.1126/science.aar1965",

language = "English",

volume = "360",

pages = "621--627",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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O’Hanlon, SJ, Rieux, A, Farrer, RA, Rosa, GM, Waldman, B, Bataille, A, Kosch, TA, Murray, KA, Brankovics, B, Fumagalli, M, Martin, MD, Wales, N, Alvarado-Rybak, M, Bates, KA, Berger, L, Böll, S, Brookes, L, Clare, F, Courtois, EA, Cunningham, AA, Doherty-Bone, TM, Ghosh, P, Gower, DJ, Hintz, WE, Höglund, J, Jenkinson, TS, Lin, CF, Laurila, A, Loyau, A, Martel, A, Meurling, S, Miaud, C, Minting, P, Pasmans, F, Schmeller, DS, Schmidt, BR, Shelton, JMG, Skerratt, LF, Smith, F, Soto-Azat, C, Spagnoletti, M, Tessa, G, Toledo, LF, Valenzuela-Sánchez, A, Verster, R, Vörös, J, Webb, RJ, Wierzbicki, C, Wombwell, E & Zamudio, KR 2018, 'Recent Asian origin of chytrid fungi causing global amphibian declines', Science, vol. 360, no. 6389, pp. 621-627. https://doi.org/10.1126/science.aar1965

TY - JOUR

T1 - Recent Asian origin of chytrid fungi causing global amphibian declines

AU - O’Hanlon, Simon J.

AU - Rieux, Adrien

AU - Farrer, Rhys A.

AU - Rosa, Gonçalo M.

AU - Waldman, Bruce

AU - Bataille, Arnaud

AU - Kosch, Tiffany A.

AU - Murray, Kris A.

AU - Brankovics, Balázs

AU - Fumagalli, Matteo

AU - Martin, Michael D.

AU - Wales, Nathan

AU - Alvarado-Rybak, Mario

AU - Bates, Kieran A.

AU - Berger, Lee

AU - Böll, Susanne

AU - Brookes, Lola

AU - Clare, Frances

AU - Courtois, Elodie A.

AU - Cunningham, Andrew A.

AU - Doherty-Bone, Thomas M.

AU - Ghosh, Pria

AU - Gower, David J.

AU - Hintz, William E.

AU - Höglund, Jacob

AU - Jenkinson, Thomas S.

AU - Lin, Chun Fu

AU - Laurila, Anssi

AU - Loyau, Adeline

AU - Martel, An

AU - Meurling, Sara

AU - Miaud, Claude

AU - Minting, Pete

AU - Pasmans, Frank

AU - Schmeller, Dirk S.

AU - Schmidt, Benedikt R.

AU - Shelton, Jennifer M.G.

AU - Skerratt, Lee F.

AU - Smith, Freya

AU - Soto-Azat, Claudio

AU - Spagnoletti, Matteo

AU - Tessa, Giulia

AU - Toledo, Luís Felipe

AU - Valenzuela-Sánchez, Andrés

AU - Verster, Ruhan

AU - Vörös, Judit

AU - Webb, Rebecca J.

AU - Wierzbicki, Claudia

AU - Wombwell, Emma

AU - Zamudio, Kelly R.

PY - 2018/5/11

Y1 - 2018/5/11

N2 - Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.

AB - Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.

UR - http://www.scopus.com/inward/record.url?scp=85046702527&partnerID=8YFLogxK

U2 - 10.1126/science.aar1965

DO - 10.1126/science.aar1965

M3 - Article

AN - SCOPUS:85046702527

SN - 0036-8075

VL - 360

SP - 621

EP - 627

JO - Science

JF - Science

IS - 6389

ER -

Recent Asian origin of chytrid fungi causing global amphibian declines

Abstract

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UN SDGs

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