Recent advances in germination of Clostridium spores

Valeria Olguín-Araneda, Saeed Banawas, Mahfuzur R. Sarker, Daniel Paredes-Sabja

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Members of Clostridium genus are a diverse group of anaerobic spore-formers that includes several pathogenic species. Their anaerobic requirement enhances the importance of the dormant spore morphotype during infection, persistence and transmission. Bacterial spores are metabolically inactive and may survive for long times in the environment and germinate in presence of nutrients termed germinants. Recent progress with spores of several Clostridium species has identified the germinant receptors (GRs) involved in nutrient germinant recognition and initiation of spore germination. Signal transduction from GRs to the downstream effectors remains poorly understood but involves the release of dipicolinic acid. Two mechanistically different cortex hydrolytic machineries are present in Clostridium spores. Recent studies have also shed light into novel biological events that occur during spore formation (accumulation of transcriptional units) and transcription during early spore outgrowth. In summary, this review will cover all of the recent advances in Clostridium spore germination.

Original languageEnglish
Pages (from-to)236-243
Number of pages8
JournalResearch in Microbiology
Issue number4
Publication statusPublished - 1 May 2015


  • Clostridium
  • Cortex hydrolysis
  • Germinant receptors
  • Germination
  • Spores

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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