Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

Franco Díaz; Camila Cores; Omar Atenas; Nicolás Rodríguez; Raúl Bustos; Pablo Cruces

doi:10.1097/INF.0000000000003169

Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

Franco Díaz, Camila Cores, Omar Atenas, Nicolás Rodríguez, Raúl Bustos, Pablo Cruces

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

Original language	English
Pages (from-to)	e259-e262
Journal	The Pediatric infectious disease journal
Volume	40
Issue number	7
DOIs	https://doi.org/10.1097/INF.0000000000003169
Publication status	Published - 1 Jul 2021

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000003169

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abstract = "Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.",

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T1 - Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

AU - Díaz, Franco

AU - Cores, Camila

AU - Atenas, Omar

AU - Rodríguez, Nicolás

AU - Bustos, Raúl

AU - Cruces, Pablo

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

AB - Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

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Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

Abstract

ASJC Scopus subject areas

UN SDGs

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