Pulmonary-renal crosstalk in the critically ill patient

Translated title of the contribution: Intercomunicación pulmón-riñón en el paciente crítico

Alejandro Donoso F., Daniela Arriagada S., Pablo Cruces R.

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Despite advances in the development of renal replacement therapy, mortality of acute renal failure remains high, especially when occurring simultaneously with distant organic failure as it is in the case of the acute respiratory distress syndrome. In this update, birideccional deleterious relationship between lung and kidney on the setting of organ dysfunction is reviewed, which presents important clinical aspects of knowing. Specifically, the renal effects of acute respiratory distress syndrome and the use of positive-pressure mechanical ventilation are discussed, being ventilator induced lung injury one of the most common models for studying the lung-kidney crosstalk. The role of renal failure induced by mechanical ventilation (ventilator-induced kidney injury) in the pathogenesis of acute renal failure is emphasized. We also analyze the impact of the acute renal failure in the lung, recognizing an increase in pulmonary vascular permeability, inflammation, and alteration of sodium and water channels in the alveolar epithelial. This conceptual model can be the basis for the development of new therapeutic strategies to use in patients with multiple organ dysfunction syndrome.

Translated title of the contributionIntercomunicación pulmón-riñón en el paciente crítico
Original languageSpanish
Pages (from-to)309-317
Number of pages9
JournalRevista Chilena de Pediatria
Issue number5
Publication statusPublished - Sept 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Intercomunicación pulmón-riñón en el paciente crítico'. Together they form a unique fingerprint.

Cite this