TY - JOUR
T1 - Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis
AU - Ciancia, Marina
AU - Quintana, Irene
AU - Vizcargüénaga, María Isabel
AU - Kasulin, Luciana
AU - de Dios, Agustina
AU - Estevez, José Manuel
AU - Cerezo, Alberto Saúl
N1 - Funding Information:
The authors are grateful to Dr. Lucía Kordich for the helpful discussion of the paper. This work was supported by grants from the University of Buenos Aires (X421, X016) and CONICET (PIP 5699).
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), α(1 → 4)-d-glucans and β(1 → 4)-d-mannans. The former polysaccharides are composed by 3-linked β-d-galactopyranose and β-l-arabinopyranose residues, they are highly sulfated and substituted with pyruvic acid ketals. For both seaweeds, they have the same main structural units, but in different percentages. All the room-temperature water extracts from both seaweeds showed a dual haemostatic effect: they prevented coagulation, but they induced platelet aggregation. Anticoagulant activity and platelet aggregation were higher in the samples with polysaccharides richer in sulfate, mainly in those from C. vermilara, which have a higher degree of sulfation and arabinose content.
AB - Codium fragile and Codium vermilara biosynthesize water-soluble sulfated arabinans and galactans (and/or sulfated arabinogalactans), α(1 → 4)-d-glucans and β(1 → 4)-d-mannans. The former polysaccharides are composed by 3-linked β-d-galactopyranose and β-l-arabinopyranose residues, they are highly sulfated and substituted with pyruvic acid ketals. For both seaweeds, they have the same main structural units, but in different percentages. All the room-temperature water extracts from both seaweeds showed a dual haemostatic effect: they prevented coagulation, but they induced platelet aggregation. Anticoagulant activity and platelet aggregation were higher in the samples with polysaccharides richer in sulfate, mainly in those from C. vermilara, which have a higher degree of sulfation and arabinose content.
KW - Anticoagulant activity
KW - Platelet aggregation
KW - Sulfated arabinogalactans
UR - http://www.scopus.com/inward/record.url?scp=35348832551&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2007.08.007
DO - 10.1016/j.ijbiomac.2007.08.007
M3 - Article
C2 - 17920674
AN - SCOPUS:35348832551
SN - 0141-8130
VL - 41
SP - 641
EP - 649
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
IS - 5
ER -