Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder

Julio Plaza-Diaz, Ana Mei Radar, Aiman Tariq Baig, Marcos Federico Leyba, Maria Macarena Costabel, Juan Pablo Zavala-Crichton, Javier Sanchez-Martinez, Alex E. MacKenzie, Patricio Solis-Urra

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms.

Original languageEnglish
Article number1834
JournalChildren
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 2022

Keywords

  • autism spectrum disorder
  • children
  • genetics
  • intestinal microbiota
  • physical activity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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