Pharmacological actions of substance P in the rat vas deferens

H. F. Miranda, W. I. Silva, W. W. Wolstenholme, N. Cuevas, A. Ucros, D. Bustamante, E. H. Fernández

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalNeuropeptides
Volume18
Issue number4
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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