Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2: A Case Series Quantitative Systematic Review

Raúl Bustos B, Juan Camilo Jaramillo-Bustamante, Pablo Vasquez-Hoyos, Pablo Cruces, Franco Díaz

Research output: Contribution to journalReview articlepeer-review

Abstract

Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July 1, 2020. We found a myriad of clinical features, but we were able to describe common characteristics: previously healthy school-aged children, persistent fever and gastrointestinal symptoms, lymphopenia, and high inflammatory markers. Clinical syndromes such as myocarditis and Kawasaki disease were present in only one third of cases each one. Pediatric intensive care unit admission was frequent, although length of stay was less than 1 week, and mortality was low. Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low. The PIMS-ST was recently described, and the detailed quantitative pooled data will increase clinicians' awareness, improve diagnosis, and promptly start treatment. This analysis also highlights the necessity of future collaborative studies, given the heterogeneous nature of the PIMS-TS.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalPediatric Emergency Care
Volume37
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • COVID-19
  • hyperinflammatory syndrome
  • Kawasaki
  • MIS-C
  • PIMS-TS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2: A Case Series Quantitative Systematic Review'. Together they form a unique fingerprint.

Cite this