Abstract
H2S production has been proposed as a mechanism to explain bacterial resistance to antibiotics. In this work, we present evidence for the role of the cysJIH operon in resistance to ciprofloxacin mediated by H2S production with different sulfate as the only sulfur source. We found that the products of the cysJIH operon are involved in ciprofloxacin resistance by increasing both, the levels of H2S and reduced thiols apparently counteracting antimicrobial-induced reactive oxygen species (ROS). This protective effect was observed only when bacteria were cultured in the presence of sulfate, but not with cysteine, as the sole sulfur source.
Original language | English |
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Pages (from-to) | 321-328 |
Number of pages | 8 |
Journal | Antibiotics |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - 31 Jul 2015 |
Keywords
- Ciprofloxacin resistance
- HS production
- JIH
- Sulfate
- Sulfur source
ASJC Scopus subject areas
- Microbiology
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)