Participation of S. Typhimurium cysJIH operon in the H2S-mediated ciprofloxacin resistance in presence of sulfate as sulfur source

Ricardo Álvarez, Jorge Frávega, Paula I. Rodas, Juan A. Fuentes, Daniel Paredes-Sabja, Iván L. Calderón, Fernando Gil

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

H2S production has been proposed as a mechanism to explain bacterial resistance to antibiotics. In this work, we present evidence for the role of the cysJIH operon in resistance to ciprofloxacin mediated by H2S production with different sulfate as the only sulfur source. We found that the products of the cysJIH operon are involved in ciprofloxacin resistance by increasing both, the levels of H2S and reduced thiols apparently counteracting antimicrobial-induced reactive oxygen species (ROS). This protective effect was observed only when bacteria were cultured in the presence of sulfate, but not with cysteine, as the sole sulfur source.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalAntibiotics
Volume4
Issue number3
DOIs
Publication statusPublished - 31 Jul 2015

Keywords

  • Ciprofloxacin resistance
  • HS production
  • JIH
  • Sulfate
  • Sulfur source

ASJC Scopus subject areas

  • Microbiology
  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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