PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications

Cecilia C. Torres; Cristian H. Campos; Carola Diáz; Verónica A. Jiménez; Felipe Vidal; Leonardo Guzmán; Joel B. Alderete

doi:10.1016/j.msec.2016.03.104

PAMAM-grafted TiO₂ nanotubes as novel versatile materials for drug delivery applications

Cecilia C. Torres, Cristian H. Campos, Carola Diáz, Verónica A. Jiménez, Felipe Vidal, Leonardo Guzmán, Joel B. Alderete

Exact Sciences School

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

PAMAM-grafted TiO₂ nanotubes (PAMAM-TiO₂NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO₂NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO₂NT nanomaterials was performed by FTIR, TEM, N₂ adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO₂NT showed a significant improvement compared to pristine TiO₂NT, thus revealing the promising properties of these new materials for drug delivery purposes.

Original language	English
Pages (from-to)	164-171
Number of pages	8
Journal	Materials Science and Engineering C
Volume	65
DOIs	https://doi.org/10.1016/j.msec.2016.03.104
Publication status	Published - 1 Aug 2016

Keywords

Drug delivery
PAMAM dendrimers
Small molecule drugs
TiO nanotubes

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1016/j.msec.2016.03.104

Cite this

@article{b90cbda19af7403db17bc750ca39dde1,

title = "PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications",

abstract = "PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.",

keywords = "Drug delivery, PAMAM dendrimers, Small molecule drugs, TiO nanotubes",

author = "Torres, {Cecilia C.} and Campos, {Cristian H.} and Carola Di{\'a}z and Jim{\'e}nez, {Ver{\'o}nica A.} and Felipe Vidal and Leonardo Guzm{\'a}n and Alderete, {Joel B.}",

note = "Funding Information: Authors thank FONDECYT Grant numbers 1130531 , 1120250 , 3140130 , and 3140157 for financial support. C. D{\'i}az and F. Vidal thank CONICYT for doctoral fellowships. ",

year = "2016",

month = aug,

day = "1",

doi = "10.1016/j.msec.2016.03.104",

language = "English",

volume = "65",

pages = "164--171",

journal = "Materials Science and Engineering C",

issn = "0928-4931",

publisher = "Elsevier BV",

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TY - JOUR

T1 - PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications

AU - Torres, Cecilia C.

AU - Campos, Cristian H.

AU - Diáz, Carola

AU - Jiménez, Verónica A.

AU - Vidal, Felipe

AU - Guzmán, Leonardo

AU - Alderete, Joel B.

N1 - Funding Information: Authors thank FONDECYT Grant numbers 1130531 , 1120250 , 3140130 , and 3140157 for financial support. C. Díaz and F. Vidal thank CONICYT for doctoral fellowships.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.

AB - PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.

KW - Drug delivery

KW - PAMAM dendrimers

KW - Small molecule drugs

KW - TiO nanotubes

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