PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications

Cecilia C. Torres, Cristian H. Campos, Carola Diáz, Verónica A. Jiménez, Felipe Vidal, Leonardo Guzmán, Joel B. Alderete

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6 wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalMaterials Science and Engineering C
Volume65
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • Drug delivery
  • PAMAM dendrimers
  • Small molecule drugs
  • TiO nanotubes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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