PAMAM-Conjugated Alumina Nanotubes as Novel Noncytotoxic Nanocarriers with Enhanced Drug Loading and Releasing Performances

Cristian H. Campos, Carola F. Díaz, José L. Guzmán, Joel B. Alderete, Cecilia C. Torres, Verónica A. Jiménez

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Alumina nanotubes are surface-conjugated with polyamidoamine (PAMAM) dendrimers of the third generation, aimed at obtaining novel nanomaterials for drug delivery applications. The structure and surface properties of PAMAM-conjugated alumina nanotubes (PAMAM-Al2O3NT) are characterized using Fourier Transform Infrared spectroscopy, solid state 13C-RMN, transmission electron microscopy, N2 adsorption–desorption isotherms, X-ray powder diffraction (XRD), and thermogravimetric analysis (TGA), which supported for a 3.0 wt% of PAMAM grafting in the prepared product. The drug loading and releasing properties of PAMAM-Al2O3NT are examined using three model therapeutic compounds, namely, curcumin, methotrexate, and silibinin, showing that PAMAM conjugation enhances the drug loading capacity and drug-adsorbent affinity compared to pristine Al2O3NT systems. Additionally, Alamar Blue cell viability assays reveal that PAMAM-Al2O3NT are not cytotoxic materials over a wide concentration range. These results suggest that PAMAM–Al2O3NT are potential nanostructured vehicles for drug delivery applications. (Figure presented.).

Original languageEnglish
Pages (from-to)1712-1722
Number of pages11
JournalMacromolecular Chemistry and Physics
Volume217
Issue number15
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • PAMAM
  • alumina nanotubes
  • drug encapsulation
  • drug release
  • surface conjugation

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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