Osteoconductive Effect of a Nanocomposite Membrane Treated with UV Radiation

Yusser Olguín, Soledad Acuna-Mendoza, Carolina Otero, Cristian A. Acevedo, Cristian Covarrubias

Research output: Contribution to journalArticlepeer-review


Modulation of the bio-regenerative characteristics of materials is an indispensable re-quirement in tissue engineering. Particularly, in bone tissue engineering, the promotion of the osteoconductive phenomenon determines the elemental property of a material be used therapeuti-cally. In addition to the chemical qualities of the constituent materials, the three-dimensional surface structure plays a fundamental role that various methods are expected to modulate in a number of ways, one most promising of which is the use of different types of radiation. In the present manuscript, we demonstrate in a calvarial defect model, that treatment with ultraviolet irradiation allows modification of the osteoconductive characteristics in a biomaterial formed by gelatin and chitosan, together with the inclusion of hydroxyapatite and titanium oxide nanoparticles.

Original languageEnglish
Article number289
Issue number2
Publication statusPublished - 1 Jan 2022


  • Biomaterials
  • Bone regeneration
  • Calvarial defect
  • Uv-treatment

ASJC Scopus subject areas

  • General Chemistry
  • Polymers and Plastics


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