Organotin Schiff bases as halofluorochromic dyes: green synthesis, chemio-photophysical characterization, DFT, and their fluorescent bioimagingin vitro

Margarita López-Espejel, Alberto Gómez-Treviño, Blanca M. Muñoz-Flores, Manuel A. Treto-Suarez, Eduardo Schott, Dayán Páez-Hernández, Ximena Zarate, Víctor M. Jiménez-Pérez

Research output: Contribution to journalArticlepeer-review

Abstract

Fluorescent bioimaging is an excellent tool in cellular biology, and it will be a powerful technique in modern medicine as a noninvasive imaging technology where tumoral and normal cells must be distinguished. One of the differences between normal and cancer cells is the intracellular pH. Therefore, the design and synthesis of pH-responsive fluorescent materials are required. Organotin Schiff bases showed halofluorochromic behavior in solution. Microwave-assisted synthesis showed better reaction times and chemical yields compared with conventional heating. All compounds were fully characterized by spectroscopic and spectrometric techniques. The halofluorochromism study showed that some molecules in acidic media have the maximum luminescence intensity due to protonation. All the fluorescent tin complexes showed cell staining on hepatocyte and MCF-7 cells by confocal microscopy. The theoretical study has enabled us to rationalize the optical properties and the halofluorochromism for compounds1and2synthesized in this work. Our results showed that the emission decrease, in the acid and basic media for compounds1and2, respectively, is caused by intramolecular charge transfer (ICT) deactivation.

Original languageEnglish
Pages (from-to)7698-7712
Number of pages15
JournalJournal of Materials Chemistry B
Volume9
Issue number37
DOIs
Publication statusPublished - 7 Oct 2021

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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