On the Existence of Synergies and the Separability of Closed Reaction Networks

Tomas Veloz, Alejandro Bassi, Pedro Maldonado, Pablo Razeto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

It is well known that closure is a necessary topological property for a reaction network to be dynamically stable. In this work we combine notions of chemical organization theory with structural properties of reaction networks to distill a minimal set of closed reaction networks that encodes the non-trivial stable dynamical regimes of the network. In particular, these non-trivial closed sets are synergetic, in the sense that their dynamics cannot always be computed from the dynamics of its closed constituents. We introduce a notion of separability for reaction networks and prove that it is strictly related to the notion of synergy. In particular, we provide a characterization of the non-trivial closed reaction networks by means of their degree of internal synergy. The less trivial the dynamics of the reaction network, the less can be separated into constituents, and equivalently the more synergies the reaction network has. We also discuss the computational and analytical benefits of this new representation of the dynamical structure of a reaction network.

Original languageEnglish
Title of host publicationMolecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers
EditorsManuel A. Martins, Madalena Chaves
PublisherSpringer Verlag
Pages105-120
Number of pages16
ISBN (Print)9783030194314
DOIs
Publication statusPublished - 1 Jan 2019
Event1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018 - Santiago, Chile
Duration: 17 Dec 201818 Dec 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11415 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018
Country/TerritoryChile
CitySantiago
Period17/12/1818/12/18

Keywords

  • Chemical organization theory
  • Closure
  • Reaction networks
  • Self-organization
  • Separability
  • Synergy

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Fingerprint

Dive into the research topics of 'On the Existence of Synergies and the Separability of Closed Reaction Networks'. Together they form a unique fingerprint.

Cite this