Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen

Pablo Valenzuela, Patrick Gray, Margarita Quiroga, Josefina Zaldivar, Howard M. Goodman, William J. Rutter

Research output: Contribution to journalArticlepeer-review

177 Citations (Scopus)

Abstract

DNA extracted from hepatitis B virus Dane particles has been cloned in bacteria using a plasmid vector. A full-length clone has been examined by restriction endonuclease analysis, and the nucleotide sequence of an 892-base pair fragment from cloned hepatitis B viral DNA encoding the surface antigen gene is reported. The amino acid sequence deduced from the DNA indicates that the surface antigen is a protein consisting of 226 amino acids and with a molecular weight of 25,398. The portion of the gene coding for this protein apparently contains no intervening sequences.

Original languageEnglish
Pages (from-to)815-819
Number of pages5
JournalNature
Volume280
Issue number5725
DOIs
Publication statusPublished - 1 Dec 1979

ASJC Scopus subject areas

  • General

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